1. Characteristics

Milican inj. is a radiopharmaceutical for treatment of hepatocellular carcinoma and hemophiliac arthritis.

A single set of Milican inj.(DW-166HC) consists of 2 vials; one is clear and transparent sterile 166Ho solution(Kit A) and the other is lyophilized sterile chitosan powder(Kit B).

The Kit A is added to Kit B to make 166Ho-chitosan complex as a clear solution in situ. It is believed that it might be possible to treat hepatocellular carcinoma(HCC) and hemophiliac arthritis(HA) with a single percutaneous intratumoral injection, and rheumatoidal arthritis(RA) with a single intra-articular injection.

Milican Film is a radiopharmaceutical which is being developed as a film for treatment of skin cancer.

2. Potential advantages

(1) Can be retained in the administration site without leakage.

(2) 166Ho has an appropriate half-life(26.8h), high 棺-energy(max 1.85MeV) and low amount and energy 款-ray(0.081MeV) easily detected by 款-camera.

(3) HCC or HA can be cured by a single intratumoral injection without surgical operation.

3. Status

(1) Milican Inj.(HCC) : Marketed

(2) Milican Film (skin cancer) : Phase II Completed

(3) Milican Inj.(HA) : in study